Promoting the great rejuvenation of the Chinese nation through Chinese-style modernization is the core theme guiding the continuous progress of the great cause in the new era and on the new journey. Coordinating the advancement of the “Four Comprehensives” strategic layout in the process of Chinese-style modernization constitutes a key support for the development of the Party and the people’s cause. This study focuses on the new stage of development, adheres to the basic methods of Marxism, and conducts an overall construction and systematic research on a series of new situations, new circumstances, and new problems faced in the coordinated advancement of the “Four Comprehensives” strategic layout in the process of Chinese-style modernization, within the dialectical unity of theory and practice, history and reality. Second, focus on the key issues of the “Four Comprehensives” strategic layout, and analyze its internal logic mechanism, unique advantages and current development status. Third, with an eye on the practical path for coordinating and advancing the “Four Comprehensives” strategic layout, on the basis of the systematic project of coordinating and advancing the “Four Comprehensives” strategic layout, construct the practical path from four aspects: handling major relationships well, improving the evaluation system, implementing specific measures well, and building a sound guarantee mechanism. This study holds that the “Four Comprehensives” strategic layout is a dynamic strategic system that interacts dialectically with the tasks of the times and maintains the vitality and vigor of development progress. Coordinating and advancing the “Four Comprehensives” strategic layout must be considered in the context of Chinese-style modernization to ensure that it leads the times and promotes the great cause steadily and far-reachingly while continuously recognizing and integrating into the times.