Sichuan is a typical inland province, and its markets before modern times exhibited obvious inward-oriented characteristics. The circulation of goods in the market was mainly regional exchanges of local products, gradually forming a single circulation system dominated by essential living supplies such as grain and salt. After the opening of ports to trade, under the transmission effects of external markets and trading ports, the structure of commodity circulation in Sichuan was reshaped. A bilateral circulation system of local and foreign goods replaced the traditional one-way cycle, significantly promoting Sichuan’s economic outward orientation and becoming the main trend in market development. In this process, Sichuan gradually established a regional market network with Chongqing and Yibin as dual cores, relying on the Yangtze River channels and various ports along the southwest border. Among them, the Eastern Sichuan market, centered on Chongqing, drove eastward openness, while the Southern Sichuan market, centered on Yibin, led southward openness, jointly radiating the market pattern to other regions of Sichuan. The coordinated development of the dual cores broke the traditional closed market pattern, advancing Sichuan’s outward-oriented market to a more open stage.